Motomiya Y, Yamada K, Matsushima S, Ijyuin M, Iriya K
Urol Res. 1975 May 30;3(1):41-8. doi: 10.1007/BF00256195.
Isozymes of urinary lactic dehydrogenase (LDH) were studied in 55 subjects, including 17 patients with bladder tumors. Normal clear urine from healthy persons showed little activity of LDH5, but in 11 out of 17 patients with bladder tumors LDH5 was increased sufficiently to invert the ratio of LDH5/LDH1, although the urine was not contaminated appreciably with leucocytes. Studies on tissue LDH isozymes in 16 tumors specimens strongly suggested that increased LDH5 in the urine of patients with bladder tumors originated from the tumors themselves. beta-Glucuronidase (B-G) isozymes were studied in urine specimens from 10 normal subjects, and 10 patients with bladder tumors and in 5 specimens of normal epithelium and 5 of tumor tissue. Two or three distinct bands of beta-G were separated from specimens of urine and tumor tissue from patients with bladder tumors, but only a single band was found in specimens from normal subjects.
对55名受试者的尿乳酸脱氢酶（LDH）同工酶进行了研究，其中包括17名膀胱肿瘤患者。健康人的正常清亮尿液中LDH5活性很低，但17名膀胱肿瘤患者中有11名的LDH5升高到足以使LDH5/LDH1的比值倒置，尽管尿液未被白细胞明显污染。对16个肿瘤标本的组织LDH同工酶研究强烈表明，膀胱肿瘤患者尿液中LDH5升高源于肿瘤本身。对10名正常受试者、10名膀胱肿瘤患者的尿液标本以及5份正常上皮组织和5份肿瘤组织标本的β-葡萄糖醛酸酶（B-G）同工酶进行了研究。从膀胱肿瘤患者的尿液和肿瘤组织标本中分离出两到三条不同的β-G条带，但在正常受试者的标本中仅发现一条带。
