[Effect of 764-3 on ventricular collagen deposition in pulmonary hypertension induced by chronic hypoxia and monocrotaline in rats].

OBJECTIVE

To observe the effect of 764-3 on ventricular collagen deposition in pulmonary hypertension induced by chronic hypoxia or monocrotaline (MCT) in rats.

METHODS

Wistar rats were divided into 10 groups. The hypobaric hypoxia group received 764-3 20 mg/kg once daily subcutaneously and the MCT group treated with 764-3 40 mg/kg once daily. The hemodynamic and biochemical parameters were measured.

RESULTS

At the time of 2 weeks and 4 weeks after treated with hypoxia or MCT, the pulmonary arterial pressure (PAP) of rats raised significantly and the right ventricular collagen content (RVCC) increased markedly. 764-3 could reduce the raised PAP induced either by hypoxia or MCT. It could lower the elevated RVCC of hypobaric hypoxia group at 2 weeks from 76.3 +/- 13.3 to 59.4 +/- 11.4 (P < 0.01), and the RVCC of MCT group lowered from 293.4 +/- 73.9 to 210.1 +/- 37.6(P < 0.01).

CONCLUSION

764-3 could partially prevent right ventricular collagen deposition induced by hypoxia and has therapeutic effect on that induced by MCT.