边缘区B细胞和B1 B细胞在针对非T细胞依赖性血源颗粒抗原的早期反应中联合起来。

Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens.

作者信息

Martin F, Oliver A M, Kearney J F

机构信息

Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

出版信息

Immunity. 2001 May;14(5):617-29. doi: 10.1016/s1074-7613(01)00129-7.

DOI:10.1016/s1074-7613(01)00129-7

PMID:11371363

Abstract

The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.

摘要

病原体清除率决定感染的程度和后果。在这种情况下，具有高度特化淋巴区室的脾脏在清除血源性病原体方面发挥着核心作用。脾脏边缘区B细胞（MZ）凭借其预激活状态和拓扑位置，在对颗粒性细菌抗原的初次应答的最初3天内，与B1 B细胞一起产生大量产生IgM的浆母细胞。由于这种应答的强度和速度，再加上所产生抗体的类型，具有“天然记忆”的脾脏MZ和B1 B细胞在非常早期的先天免疫和随后出现的适应性免疫应答之间架起了一座桥梁。