Guo C X, Tang T S, Liu Y X
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080.
Sheng Li Ke Xue Jin Zhan. 2000 Oct;31(4):299-304.
Both spontaneous and induced germ cell apoptosis occur during the process of germ cell differentiation in testis, which is an important mechanism to remove surplus and abnormal germ cells. It has been known that germ cell apoptosis is under the control of endocrine, cell social association and gene. To elucidate the molecular mechanisms by which germ cell apoptosis is regulated and the elements of the death machinery will provide a basis for effective management of male infertility as well as more targeted approaches to male contraception.
在睾丸生殖细胞分化过程中,自发和诱导的生殖细胞凋亡都会发生,这是清除多余和异常生殖细胞的重要机制。已知生殖细胞凋亡受内分泌、细胞社交联系和基因的控制。阐明调节生殖细胞凋亡的分子机制以及死亡机制的要素,将为有效治疗男性不育症以及更有针对性的男性避孕方法提供依据。