细胞角蛋白7和20在腺癌脑转移诊断中的价值：78例研究

[Value of cytokeratin 7 and 20 for the diagnosis of cerebral metastases of adenocarcinoma: study of 78 cases].

作者信息

Fernandez C, Liprandi A, Bouvier-Labit C, Figarella-Branger D

机构信息

Service d'Anatomie Pathologique, CHU Timone, 264 rue Saint-Pierre, 13385 Marseille cédex 05.

出版信息

Ann Pathol. 2001 Apr;21(2):129-35.

PMID:11373582

Abstract

OBJECTIVE

histological features of metastasis are not always specific of the origin. The usefulness of cytokeratin 7 and 20 (CK7 and CK20) in cerebral metastases from an adenocarcinoma was studied in a series of 78 patients.

RESULTS

metastases from lung adenocarcinoma showed a CK7+/CK20- pattern in 79% of cases, CK7+/CK20+ in 19% and CK7-/CK20- in 2%. When observed, positivity for cytokeratin 20 was generally focal or weak. Breast adenocarcinoma metastases were CK7+/CK20- in 71% of cases and CK7-/CK20- in 29%. Less differentiated tumours were usually negative for both cytokeratins. Metastases by colonic adenocarcinoma were CK7-/CK20+ in 100% of cases. Cytokeratins 7 and 20 are useful to distinguish lung from colonic metastatic carcinoma. In case of double positivity, a more intense CK7 expression is rather suggestive of a lung origin.

CONCLUSION

these results might modify paraclinic investigations in search of the primitive tumor.

摘要

目的

转移瘤的组织学特征并非总是起源特异性的。在78例患者中研究了细胞角蛋白7和20（CK7和CK20）在腺癌脑转移中的应用价值。

结果

肺腺癌转移瘤79%表现为CK7+/CK20-模式，19%为CK7+/CK20+，2%为CK7-/CK20-。若观察到细胞角蛋白20阳性，通常为局灶性或弱阳性。乳腺腺癌转移瘤71%为CK7+/CK20-，29%为CK7-/CK20-。分化较差的肿瘤通常两种细胞角蛋白均为阴性。结肠腺癌转移瘤100%为CK7-/CK20+。细胞角蛋白7和20有助于区分肺转移癌和结肠转移癌。出现双阳性时，CK7表达更强提示起源于肺。