[低密度脂蛋白分离术：现状]
[LDL-apheresis: current status].
作者信息
Stefanutti C, Vivenzio A, Lucani G, Di Giacomo S
机构信息
Sezione di Plasmaferesi Terapeutica, Istituto di Terapia Medica Sistematica, Policlinico Umberto I, Università degli Studi di Roma La Sapienza, Roma, Italia.
出版信息
Clin Ter. 2001 Jan-Feb;152(1):65-9.
PURPOSE
State of the art of LDL-apheresis and treatment of severe familiar hypercholesterolemia.
PATIENTS AND METHODS
Clinical experience of treatment with LDL-apheresis of pediatric and adult patients with familial hypercholesterolemia using the following techniques: D.A.L.I., H.E.L.P., D.S.C.
RESULTS
The outcome of treatment with LDL-apheresis in young patients, using the most recently introduced techniques, is reported. We have submitted to LDL-apheresis 11 pediatric patients. The youngest is aged 3.5. LDL-apheresis is able at improving the metabolic impairment and halting the natural evolution of atherosclerotic disease and atherosclerotic complications.
CONCLUSIONS
At present, LDL-apheresis is the most effective and safe therapeutic approach to the treatment of homozygous, heterozygous and double heterozygous familial hypercholesterolemia.
目的
低密度脂蛋白分离术的现状及重度家族性高胆固醇血症的治疗。
患者与方法
采用以下技术（D.A.L.I.、H.E.L.P.、D.S.C.）对儿童和成年家族性高胆固醇血症患者进行低密度脂蛋白分离术治疗的临床经验。
结果
报告了采用最新技术对年轻患者进行低密度脂蛋白分离术的治疗结果。我们已让11名儿科患者接受低密度脂蛋白分离术治疗。最年幼的患者为3.5岁。低密度脂蛋白分离术能够改善代谢障碍并阻止动脉粥样硬化疾病及动脉粥样硬化并发症的自然发展。
结论
目前，低密度脂蛋白分离术是治疗纯合子、杂合子及双杂合子家族性高胆固醇血症最有效且安全的治疗方法。
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