Leibowitz Matthew R., Mitsuyasu Ronald T.
UCLA Center for Clinical AIDS Research and Education, 10833 Le Conte Avenue, BH-412 CHS, Los Angeles, CA 90095-1793, USA
Curr Infect Dis Rep. 2001 Jun;3(3):302-308. doi: 10.1007/s11908-001-0034-3.
Although potent antiretroviral therapy can dramatically decrease HIV replication and improve some aspects of host immunity, incomplete immune reconstitution persists even after several years of fully suppressive therapy. In addition, long-term toxicities of antiretroviral medications and the probability of developing multidrug-resistant virus with long-term use indicate that alternate means of controlling viral replication are needed for more durable suppression of HIV. Immune-based therapies may help potentiate the host's own defenses against HIV and other pathogens, and may ultimately result in more durable viral suppression and lower incidence of antiretroviral therapy-related side effects and toxicities.
尽管强效抗逆转录病毒疗法能显著降低HIV复制并改善宿主免疫的某些方面，但即使经过数年完全抑制性治疗，免疫重建仍不完全。此外，抗逆转录病毒药物的长期毒性以及长期使用产生多药耐药病毒的可能性表明，需要其他控制病毒复制的方法来更持久地抑制HIV。基于免疫的疗法可能有助于增强宿主自身对HIV和其他病原体的防御能力，并最终可能导致更持久的病毒抑制以及抗逆转录病毒治疗相关副作用和毒性的发生率降低。
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