Calter M A, Guo X, Liao W
Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, USA.
Org Lett. 2001 May 17;3(10):1499-501. doi: 10.1021/ol015814e.
[reaction: see text] The opening of methylketene dimer, followed by aldol reactions of the resulting enolate, provides a convenient access to syn,syn-dipropionate aldol adducts of a variety of aldehydes. These aldol adducts are useful precursors in the synthesis of complex polypropionates.
[反应：见正文] 甲基乙烯酮二聚体开环，随后生成的烯醇盐进行羟醛反应，为各种醛的顺式、顺式-二丙酸酯羟醛加合物提供了便捷的合成方法。这些羟醛加合物是合成复杂聚丙酸酯的有用前体。
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