巴泽拉汀A双环胍核心的合成及绝对构型测定

Synthesis and determination of absolute configuration of the bicyclic guanidine core of batzelladine A.

作者信息

Duron S G, Gin D Y

机构信息

Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA.

出版信息

Org Lett. 2001 May 17;3(10):1551-4. doi: 10.1021/ol015848m.

DOI:10.1021/ol015848m

PMID:11388864

Abstract

[reaction: see text] The synthesis of a selectively protected form of the bicyclic guanidine fragment of batzelladine A from L-aspartic acid is reported, thereby establishing the absolute configuration of the bicyclic guanidine ring system within the natural product.

摘要

[反应：见正文] 报道了从L-天冬氨酸合成巴兹拉定A双环胍片段的一种选择性保护形式，从而确定了天然产物中双环胍环系统的绝对构型。