钙离子激活的氯离子通道：一个新出现的阴离子转运家族。
Ca(2+)-Activated Cl(-) Channels: A Newly Emerging Anion Transport Family.
作者信息
Fuller Catherine M., Benos Dale J.
机构信息
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
出版信息
News Physiol Sci. 2000 Aug;15:165-171.
PMID:11390902
Abstract
A new family of Cl(-) channels widely expressed in epithelia has been identified. These proteins are associated with Ca(2+)-sensitive conductive Cl(-) transport when heterologously expressed. This family may underlie the Ca(2+)-mediated Cl(-) conductance responsible for rescue of the cystic fibrosis knockout mouse from significant airway disease.
摘要
已鉴定出一个广泛表达于上皮细胞的新型氯离子通道家族。这些蛋白质在异源表达时与钙敏感的氯离子传导性转运相关。该家族可能是囊性纤维化基因敲除小鼠从严重气道疾病中获救所涉及的钙介导氯离子电导的基础。
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