胃肌电活动与心脏副交感神经活动与化疗所致恶心的关系
Relationship of gastric myoelectrical and cardiac parasympathetic activity to chemotherapy-induced nausea.
作者信息
Gianaros P J, Stern R M, Morrow G R, Hickok J T
机构信息
Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
J Psychosom Res. 2001 May;50(5):263-6. doi: 10.1016/s0022-3999(01)00201-x.
OBJECTIVES
We evaluated (a) whether pretreatment levels of gastric tachyarrhythmia, a dysrhythmic pattern of gastric myoelectrical activity, or cardiac parasympathetic activity are associated with the development of chemotherapy-induced nausea and (b) whether chemotherapy-induced nausea is preceded by an increase in gastric tachyarrhythmia and a decrease in cardiac parasympathetic activity, as has been observed during motion sickness.
METHODS
Electrogastrograms and estimates of respiratory sinus arrhythmia (RSA) were obtained from cancer chemotherapy patients before treatment and for approximately 24 hours after treatment.
RESULTS
Higher levels of pretreatment gastric tachyarrhythmia were observed on chemotherapy sessions that were followed by posttreatment reports of nausea. Pretreatment levels of RSA, however, did not differ between chemotherapy treatments that were and were not followed by nausea. No statistically significant changes in gastric tachyarrhythmia or RSA were observed prior to first reports of nausea following chemotherapy.
CONCLUSIONS
In contrast to motion sickness, chemotherapy-induced nausea may not be related to an increase in dysrhythmic gastric myoelectrical activity; however, higher levels of pretreatment gastric tachyarrhythmia may be related to posttreatment reports of chemotherapy-induced nausea.
目的
我们评估了（a）胃快速心律失常（一种胃肌电活动的节律异常模式）或心脏副交感神经活动的预处理水平是否与化疗引起的恶心的发生有关，以及（b）化疗引起的恶心是否如晕动病期间所观察到的那样，在胃快速心律失常增加和心脏副交感神经活动减少之前出现。
方法
从癌症化疗患者治疗前及治疗后约24小时获取胃电图和呼吸性窦性心律失常（RSA）的评估值。
结果
在后续有治疗后恶心报告的化疗疗程中，观察到预处理时胃快速心律失常水平较高。然而，在后续有恶心和无恶心的化疗治疗之间，预处理时的RSA水平没有差异。在化疗后首次出现恶心报告之前，未观察到胃快速心律失常或RSA有统计学显著变化。
结论
与晕动病不同，化疗引起的恶心可能与节律异常的胃肌电活动增加无关；然而，预处理时较高水平的胃快速心律失常可能与化疗引起的恶心的治疗后报告有关。
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