肠炎沙门氏菌鼠伤寒血清型DT104毒力的体外和体内评估。
In vitro and in vivo assessment of Salmonella enterica serovar Typhimurium DT104 virulence.
作者信息
Allen C A, Fedorka-Cray P J, Vazquez-Torres A, Suyemoto M, Altier C, Ryder L R, Fang F C, Libby S J
机构信息
Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695.
出版信息
Infect Immun. 2001 Jul;69(7):4673-7. doi: 10.1128/IAI.69.7.4673-4677.2001.
Abstract
Multidrug-resistant Salmonella enterica serovar Typhimurium phage type DT104 has become a widespread cause of human and other animal infection worldwide. The severity of clinical illness in S. enterica serovar Typhimurium DT104 outbreaks has led to the suggestion that this strain possesses enhanced virulence. In the present study, in vitro and in vivo virulence-associated phenotypes of several clinical isolates of S. enterica serovar Typhimurium DT104 were examined and compared to S. enterica serovar Typhimurium ATCC 14028s. The ability of these DT104 isolates to survive within murine peritoneal macrophages, invade cultured epithelial cells, resist antimicrobial actions of reactive oxygen and nitrogen compounds, and cause lethal infection in mice were assessed. Our results failed to demonstrate that S. enterica serovar Typhimurium DT104 isolates are more virulent than S. enterica serovar Typhimurium ATCC 14028s.
摘要
多重耐药性肠炎沙门氏菌鼠伤寒血清型DT104噬菌体类型已成为全球范围内人类和其他动物感染的广泛病因。肠炎沙门氏菌鼠伤寒血清型DT104暴发中临床疾病的严重性引发了这样的推测，即该菌株具有增强的毒力。在本研究中，检测了肠炎沙门氏菌鼠伤寒血清型DT104的几种临床分离株的体外和体内毒力相关表型，并与肠炎沙门氏菌鼠伤寒血清型ATCC 14028s进行了比较。评估了这些DT104分离株在小鼠腹腔巨噬细胞内存活、侵入培养的上皮细胞、抵抗活性氧和氮化合物的抗菌作用以及在小鼠中引起致死性感染的能力。我们的结果未能证明肠炎沙门氏菌鼠伤寒血清型DT104分离株比肠炎沙门氏菌鼠伤寒血清型ATCC 14028s的毒力更强。
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