白色念珠菌的菌丝和酵母对人血单核细胞白细胞介素-12的产生有不同调节作用：白色念珠菌萌发的抑制作用
Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination.
作者信息
Liu L, Kang K, Takahara M, Cooper K D, Ghannoum M A
机构信息
The Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio.
出版信息
Infect Immun. 2001 Jul;69(7):4695-7. doi: 10.1128/IAI.69.7.4695-4697.2001.
Abstract
The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.
摘要
研究了白色念珠菌酵母-菌丝转变在单核细胞产生白细胞介素-12（IL-12）中的作用。萌发的白色念珠菌不仅未能诱导IL-12 p70产生，还抑制了热灭活白色念珠菌诱导的IL-12产生。比较萌发的白色念珠菌和不萌发突变体抑制IL-12产生的能力，结果表明白色念珠菌的萌发在抑制IL-12产生中起关键作用。
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