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成釉细胞瘤:71例临床、影像学及组织病理学分析

Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases.

作者信息

Kim S G, Jang H S

机构信息

Department of Oral and Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University, Kwang-Ju, Korea.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jun;91(6):649-53. doi: 10.1067/moe.2001.114160.


DOI:10.1067/moe.2001.114160
PMID:11402276
Abstract

OBJECTIVES: The purpose of this study was to compare the clinical, radiologic, and histopathologic features of 71 intraosseous ameloblastomas. STUDY DESIGN: Data with respect to the patients' ages, sex, tumor locations, and surgical treatment history, as well as the radiographic findings and number of recurrences, were analyzed. The histologic types of and radiologic findings regarding tumors with higher recurrence rates were also investigated. RESULTS: The patients' ages at biopsy ranged from 11 to 70 years (mean, 30.4 years). Thirty-nine (54.9%) of the 71 subjects were males, and 32 (45.1%) were females. Sixty-two (87.3%) of the 71 ameloblastomas were located in the mandible. Swelling was the most common symptom and was experienced by 27 (38.0%) patients. Radiographically, 42 (59.2%) of the 71 tumors were unilocular with a well-demarcated border. Of the remaining 29 cases, 14 were multilocular, 2 were of soap-bubble shape, and 13 were unknown in appearance. The most common histologic pattern was plexiform, rather than follicular or acanthomatous. Sixteen cases of ameloblastoma had developed in a cyst. The overall recurrence rate was 21.1%, and the average age of the patient at recurrence was 26.4 years. CONCLUSIONS: When the diagnosis of ameloblastoma in young people remains in doubt after clinical and radiologic examination, a biopsy is necessary. Long-term follow-up at regular intervals after surgery is also recommended.

摘要

目的:本研究旨在比较71例骨内成釉细胞瘤的临床、影像学和组织病理学特征。 研究设计:分析了患者的年龄、性别、肿瘤位置、手术治疗史,以及影像学表现和复发次数。还调查了复发率较高的肿瘤的组织学类型和影像学表现。 结果:活检时患者年龄在11至70岁之间(平均30.4岁)。71例受试者中,39例(54.9%)为男性,32例(45.1%)为女性。71例成釉细胞瘤中有62例(87.3%)位于下颌骨。肿胀是最常见的症状,27例(38.0%)患者出现该症状。影像学上,71例肿瘤中有42例(59.2%)为单房性,边界清晰。其余29例中,14例为多房性,2例呈肥皂泡状,13例外观不明。最常见的组织学模式是丛状,而非滤泡状或棘皮瘤状。16例成釉细胞瘤发生于囊肿内。总体复发率为21.1%,复发时患者的平均年龄为26.4岁。 结论:当年轻人成釉细胞瘤的诊断在临床和影像学检查后仍存疑问时,有必要进行活检。术后也建议定期进行长期随访。

相似文献

[1]
Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001-6

[2]
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Am J Surg Pathol. 2000-10

[3]
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[4]
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Diagn Cytopathol. 2013-3

[5]
Long-term follow up on recurrence of 305 ameloblastoma cases.

Int J Oral Maxillofac Surg. 2007-4

[6]
Prognostic evaluation of ameloblastoma based on histologic and radiographic typing.

J Oral Maxillofac Surg. 1989-1

[7]
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Int J Oral Surg. 1984-6

[8]
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J Oral Maxillofac Surg. 2003-1

[9]
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J Oral Maxillofac Surg. 2005-6

[10]
Clinicopathological characteristics of ameloblastomas in Western Uttar Pradesh population: An institutional study.

Indian J Cancer. 2015

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Reports (MDPI). 2024-11-7

[2]
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Cureus. 2025-5-29

[3]
Comparison of computed tomographic findings for radiolucent lesions of the mandibular ameloblastoma, odontogenic keratocyst, dentigerous cyst, and simple bone cyst.

J Dent Sci. 2025-1

[4]
Multidisciplinary Approach to Mandibular Ameloblastoma: A Case Report on Surgical and Prosthetic Management.

Am J Case Rep. 2024-9-25

[5]
The radiologic progression of ameloblastomas.

SA J Radiol. 2023-5-31

[6]
Ameloblastoma: Retrospective Study and Analysis of 102 Cases Over 10 Years, Single Centre, Institutional Experience.

J Maxillofac Oral Surg. 2022-6

[7]
Analysis of the 100 most cited articles on ameloblastoma.

Oral Maxillofac Surg. 2023-9

[8]
Effectiveness of the Conservative Surgical Management of the Ameloblastomas: A Cross-Sectional Study.

Front Oral Health. 2021-10-29

[9]
Acanthomatous Ameloblastoma: An Early Stage Case Report with Difficult Management.

Case Rep Dent. 2021-6-18

[10]
Wide Excision with Immediate Reconstruction of the Mandible Using Free Fibular Flap in Ameloblastoma of the Mandible-A Need of Time: Our Experience of 37 Cases.

Indian J Plast Surg. 2020-12

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