Pedersen T, Pedersen P, Moller A M
Department of Anaesthesiology, Bispebjerg University Hospital, 23 Bispebjerg Bakke, 2400 NV Copenhagen, Denmark.
Cochrane Database Syst Rev. 2001(2):CD002013. doi: 10.1002/14651858.CD002013.
Monitoring with pulse oximetry might improve patient outcome by enabling an early diagnosis and consequently, correction of perioperative events that might cause postoperative complications or even death. Only a few randomised clinical trials of pulse oximetry have been performed during anaesthesia and in the recovery room which describe perioperative hypoxaemic events, postoperative cardiopulmonary complications and cognitive dysfunction.
To study the effect of perioperative monitoring with pulse oximetry to clearly identify the adverse outcomes that might be prevented or improved by the use of pulse oximetry.
Trials were identified by computerised searches of the Cochrane Library, MEDLINE, EMBASE, and by checking the reference lists of trials and review articles.
All controlled trials that randomised patients to either pulse oximetry or no pulse oximetry during the perioperative period, including the operating and recovery room.
We collected data in relation to events detectable by pulse oximetry, any serious complications that occurred during anaesthesia or in the postoperative period, intra- or postoperative mortality, and duration of recovery or intensive care stay. Formal statistical synthesis of individual trials was not performed in view of the variety of outcomes studied.
Searching identified six reports; four studies with data from a total of 21,773 patients were considered eligible for analysis. Only two studies specifically addressed the outcomes in question; both found no effect on the rate of postoperative complications using perioperative pulse oximetry. Two studies used hypoxaemia detectable by pulse oximetry to assess the value of perioperative monitoring, although outcomes were not given. It was found that hypoxaemia was reduced in the pulse oximetry group both in the operating theatre and in the recovery room. During observation in the recovery room, the incidence of hypoxaemia in the pulse oximetry group was 1.5-3 times less. The postoperative cognitive function using the Wechsler memory scale and continuous reaction time was independent of perioperative monitoring with pulse oximetry. The other study showed that postoperative complications occurred in 10% of the patients in the oximetry group and in 9.4% in the control group. The two groups did not differ in cardiovascular, respiratory, neurologic, or infectious complications. The duration of hospital stay was a median of 5 days in both groups, and an equal number of in-hospital deaths was registered in the two groups.
REVIEWER'S CONCLUSIONS: The studies confirmed that pulse oximetry can detect hypoxaemia and related events. However, we have found no evidence that pulse oximetry affects the outcome of anaesthesia. The conflicting subjective and objective results of the studies, despite an intense, methodical collection of data from a relatively large population, indicates that the value of perioperative monitoring with pulse oximetry is questionable in relation to improved reliable outcomes, effectiveness and efficiency.
通过脉搏血氧饱和度监测能够实现早期诊断,进而纠正可能导致术后并发症甚至死亡的围手术期事件,这或许可以改善患者的预后。在麻醉期间及恢复室中,仅开展了少数关于脉搏血氧饱和度监测的随机临床试验,这些试验描述了围手术期低氧血症事件、术后心肺并发症及认知功能障碍。
研究围手术期脉搏血氧饱和度监测的效果,以明确使用脉搏血氧饱和度监测可能预防或改善的不良结局。
通过计算机检索Cochrane图书馆、MEDLINE、EMBASE来识别试验,并查阅试验及综述文章的参考文献列表。
所有将患者随机分为围手术期(包括手术室和恢复室)接受脉搏血氧饱和度监测或不接受该监测的对照试验。
我们收集了与脉搏血氧饱和度监测可检测到的事件、麻醉期间或术后发生的任何严重并发症、术中和术后死亡率以及恢复或重症监护停留时间相关的数据。鉴于所研究结局的多样性,未对各个试验进行正式的统计综合分析。
检索共识别出6篇报告;4项研究的数据来自总共21773例患者,被认为符合分析条件。仅有2项研究专门针对所讨论的结局;两者均发现围手术期使用脉搏血氧饱和度监测对术后并发症发生率无影响。2项研究使用脉搏血氧饱和度可检测到的低氧血症来评估围手术期监测的价值,不过未给出结局。结果发现,脉搏血氧饱和度监测组在手术室和恢复室中的低氧血症均有所减少。在恢复室观察期间,脉搏血氧饱和度监测组的低氧血症发生率低1.5至3倍。使用韦氏记忆量表和连续反应时间评估的术后认知功能与围手术期脉搏血氧饱和度监测无关。另一项研究表明,血氧饱和度监测组10%的患者发生了术后并发症,对照组为9.4%。两组在心血管、呼吸、神经或感染性并发症方面无差异。两组的住院时间中位数均为5天,两组的院内死亡人数相同。
这些研究证实脉搏血氧饱和度监测能够检测到低氧血症及相关事件。然而,我们未发现证据表明脉搏血氧饱和度监测会影响麻醉结局。尽管从相对大量的人群中进行了密集、系统的数据收集,但研究中主观和客观结果相互矛盾,这表明围手术期脉搏血氧饱和度监测在改善可靠结局、有效性和效率方面的价值存疑。