Kartalou M, Essigmann J M
Department of Chemistry, Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Mutat Res. 2001 Jul 1;478(1-2):1-21. doi: 10.1016/s0027-5107(01)00142-7.
Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA and forms 1,2-d(ApG), 1,2-d(GpG) and 1,3-d(GpTpG) intrastrand crosslinks, interstrand crosslinks and monofunctional adducts. The presence of these adducts in DNA is through to be responsible for the therapeutic efficacy of cisplatin. The exact signal transduction pathway that leads to cell cycle arrest and cell death following treatment with the drug is not known but cell death is believed to be mediated by the recognition of the adducts by cellular proteins. Here we describe the structural information available for cisplatin and related platinum adducts, the interactions of the adducts with cellular proteins and the implications of these interactions for cell survival.
顺铂是一种广泛使用的化疗药物。它与DNA中的亲核碱基发生反应，形成1,2 - d(ApG)、1,2 - d(GpG)和1,3 - d(GpTpG)链内交联、链间交联和单功能加合物。DNA中这些加合物的存在被认为是顺铂治疗效果的原因。在用该药物治疗后导致细胞周期停滞和细胞死亡的确切信号转导途径尚不清楚，但细胞死亡被认为是由细胞蛋白识别加合物介导的。在这里，我们描述了可获得的顺铂及相关铂加合物的结构信息、加合物与细胞蛋白的相互作用以及这些相互作用对细胞存活的影响。
