内侧颞叶起源的病灶性癫痫的成功放射外科治疗。

Successful radiosurgical treatment of lesional epilepsy of mesial temporal origin.

作者信息

Kurita H, Suzuki I, Shin M, Kawai K, Tago M, Momose T, Kirino T

机构信息

Department of Neurosurgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

出版信息

Minim Invasive Neurosurg. 2001 Mar;44(1):43-6. doi: 10.1055/s-2001-13586.

DOI:10.1055/s-2001-13586

PMID:11409311

Abstract

We report a case of successful radiosurgical treatment of lesional epilepsy of mesial temporal origin. A patient presented with a 2-year history of medically intractable complex partial seizures associated with a mesial temporal angioma. Interictal scalp EEG and MEG showed focal epileptiform activity around the lesion. 99mTc-HMPAO-SPECT and 18F-FDG-PET demonstrated depressed blood flow and glucose metabolism in the corresponding temporal lobe. The patient underwent gamma knife radiosurgery for the causative lesion with a low marginal dose of 18 Gy. After treatment, the partial attack ceased without shrinkage of the lesion or peri-lesional parenchymal radiation injury.

摘要

我们报告一例成功通过放射外科治疗起源于颞叶内侧的病灶性癫痫的病例。一名患者有2年药物难治性复杂部分性发作病史，伴有颞叶内侧血管瘤。发作间期头皮脑电图和脑磁图显示病灶周围有局灶性癫痫样活动。99mTc-HMPAO单光子发射计算机断层扫描和18F-氟代脱氧葡萄糖正电子发射断层扫描显示相应颞叶血流和葡萄糖代谢降低。该患者因致病病灶接受了伽玛刀放射外科治疗，边缘低剂量为18 Gy。治疗后，部分发作停止，病灶无缩小，病灶周围实质无放射性损伤。