Nibu K, Kondo K, Ohta Y, Ishibashi T, Rothstein J L, Kaga K
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Japan.
Neuroreport. 2001 Jun 13;12(8):1615-9. doi: 10.1097/00001756-200106130-00021.
To better understand the roles of NeuroD, a member of the basic helix-loop-helix transcription factor family, during the differentiation of olfactory receptor neurons, we studied the expression of NeuroD in developing and aging mouse olfactory epithelium (OE). During embryonic period, NeuroD expression is confined in the basal compartment of OE. During neonatal period, NeuroD expression is detected in the middle compartment and in the basal compartment of OE. In the adult, the number of NeuroD expressing cells in the basal compartment significantly decreased, while the NeuroD-positive cells in the middle compartment was maintained throughout lifetime. This dual phase expression pattern of NeuroD suggests multiple roles of NeuroD in the neurogenesis of ORNs.
为了更好地理解碱性螺旋-环-螺旋转录因子家族成员NeuroD在嗅觉受体神经元分化过程中的作用，我们研究了NeuroD在发育中和衰老的小鼠嗅觉上皮（OE）中的表达。在胚胎期，NeuroD的表达局限于OE的基底区。在新生期，在OE的中区和基底区检测到NeuroD的表达。在成年小鼠中，基底区表达NeuroD的细胞数量显著减少，而中区的NeuroD阳性细胞在整个生命周期中保持稳定。NeuroD的这种双相表达模式表明NeuroD在ORN神经发生中具有多种作用。
