对来自地理上不同区域的家猫和野猫物种的猫泡沫病毒分离株的遗传分析。

Genetic analyses of feline foamy virus isolates from domestic and wild feline species in geographically distinct areas.

作者信息

Phung H T, Ikeda Y, Miyazawa T, Nakamura K, Mochizuki M, Izumiya Y, Sato E, Nishimura Y, Tohya Y, Takahashi E, Mikami T

机构信息

Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, 113-8657, Tokyo, Japan.

出版信息

Virus Res. 2001 Aug;76(2):171-81. doi: 10.1016/s0168-1702(01)00275-1.

DOI:10.1016/s0168-1702(01)00275-1

PMID:11410316

Abstract

To know the genetic diversities and phylogenetic relationship among feline foamy virus (FeFV) isolates from domestic cats (Felis catus) and FeFV-related viruses from the Iriomote cats (Felis iriomotensis) and leopard cats (Felis bengalensis) in geographically distinct areas, we sequenced a partial gag-pol region of 17 strains and a partial env region of nine strains, and the U3 region of long terminal repeat of three strains of the viruses. FeFV-related viruses from the feral cats were quite similar to the FeFV from domestic cats in the sequenced regions. In the partial gag region, the identities of nucleotide sequences among the isolates were from 94 to 99%. In the partial env gene, the isolates were divided into two distinct genotypes (F17- and FUV-types) as reported by Winkler et al. (Virology 247 (1999) 144-151). More than 94% nucleotide identities were observed in the env region within a particular env genotype and about 75% nucleotide identities were noted between the two genotypes.

摘要

为了解来自不同地理区域的家猫（Felis catus）的猫泡沫病毒（FeFV）分离株与来自冲绳野猫（Felis iriomotensis）和豹猫（Felis bengalensis）的FeFV相关病毒之间的遗传多样性和系统发育关系，我们对17个毒株的部分gag-pol区域、9个毒株的部分env区域以及3个毒株的病毒长末端重复序列的U3区域进行了测序。来自野猫的FeFV相关病毒在测序区域与家猫的FeFV非常相似。在部分gag区域，分离株之间核苷酸序列的同一性为94%至99%。在部分env基因中，如Winkler等人（《病毒学》247（1999）144 - 151）所报道，分离株被分为两种不同的基因型（F17 - 和FUV - 型）。在特定env基因型的env区域内观察到超过94%的核苷酸同一性，而两种基因型之间的核苷酸同一性约为75%。