[内源性精神病患者血清素2a型（5-HTR2A）受体基因多态性与人格特质]

[Serotonin type 2a (5-HTR2A) receptor gene polymorphism and personality traits in patients with endogenous psychoses].

作者信息

Golimbet V E, Alfimova M V, Manandian K K, Abramova L I, Kaleda V G, Mitiushina N G, Oleĭchik I V, Iurov Iu B, Trubnikov V I

机构信息

Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 113152 Russia.

出版信息

Genetika. 2001 Apr;37(4):545-8.

PMID:11421130

Abstract

Genetic polymorphism of the serotonin receptor (5-HTR2A) gene has been reported to be associated with the expression of clinical signs characteristic of major psychoses, including schizophrenia and affective disorders. In this study, personality traits of patients with these diseases and the associations of these traits with 5-HTR2A allelic polymorphisms were studied. It was demonstrated that schizophrenic and affective patients with the 2/2 genotype of serotonin receptor had lower scores on the anxiety scale and on the anxiety-related hypochondriasis and neuroticism scales than subjects with the 1/1 and 1/2 genotypes.

摘要

据报道，血清素受体（5-HTR2A）基因的遗传多态性与包括精神分裂症和情感障碍在内的主要精神病临床症状特征的表达有关。在本研究中，对患有这些疾病患者的人格特质以及这些特质与5-HTR2A等位基因多态性的关联进行了研究。结果表明，与具有1/1和1/2基因型的受试者相比，具有血清素受体2/2基因型的精神分裂症和情感障碍患者在焦虑量表、与焦虑相关的疑病症量表和神经质量表上的得分较低。