Davidovich U, de Wit J, Albrecht N, Geskus R, Stroebe W, Coutinho R
Division of Public Health, Amsterdam Municipal Health Service, The Netherlands.
AIDS. 2001 Jul 6;15(10):1303-8. doi: 10.1097/00002030-200107060-00013.
To examine the share of steady versus casual partners as the source of HIV infection in gay male seroconversions between 1984 and 2000 and the effect of age at seroconversion on the source of HIV transmission.
The sample consisted of 144 seroconverstors from the Amsterdam Cohort Study among Homosexual Men. Questionnaires and post-seroconversion interviews were used to determine the source of HIV transmission.
Analysis revealed an interaction effect between calendar year and age at seroconversion (P < 0.05). Younger seroconverters had higher odds ratios [odds ratio, 11.33; 95% confidence interval, 1.77--72.13] to be infected by their steady partner late in the AIDS epidemic: 15% (three of 20) between 1984 and 1987 versus 67% (six of nine) between 1994 and 2000. No such time effect was present for older seroconverters who were consistently more likely to be infected by a casual partner: 79% (37 of 47) between 1984 and 1987, and 83% (15 of 18) between 1994 and 2000.
Young gay seroconverters today are more likely to have contracted HIV from a steady partner than from a casual partner, compared with early in the AIDS epidemic and compared also with older gay seroconverters. There is a pressing need for preventive measures addressing sexual risk behaviour within steady relationships among younger gay men.
研究1984年至2000年间男同性恋者血清转化时，固定性伴侣与临时性伴侣作为HIV感染源的比例，以及血清转化时的年龄对HIV传播源的影响。
样本来自阿姆斯特丹男同性恋队列研究中的144名血清转化者。通过问卷调查和血清转化后的访谈来确定HIV传播源。
分析显示，年份与血清转化时的年龄之间存在交互作用（P<0.05）。在艾滋病流行后期，较年轻的血清转化者被其固定性伴侣感染的比值比更高[比值比，11.33；95%置信区间，1.77 - 72.13]：1984年至1987年间为15%（20例中的3例），而1994年至2000年间为67%（9例中的6例）。年龄较大的血清转化者则不存在这种时间效应，他们一直更有可能被临时性伴侣感染：1984年至1987年间为79%（47例中的37例），1994年至2000年间为83%（18例中的15例）。
与艾滋病流行早期相比，也与年龄较大的男同性恋血清转化者相比，如今年轻的男同性恋血清转化者更有可能从固定性伴侣而非临时性伴侣那里感染HIV。迫切需要针对年轻男同性恋者固定关系中的性风险行为采取预防措施。
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