Effect of ACTH on pain sensitivity in rats.

作者信息

Bogdanov A I, Yarushkina N I

机构信息

Department of Physiology of Endocrine System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.

出版信息

Bull Exp Biol Med. 2001 Mar;131(3):216-8. doi: 10.1023/a:1017609726742.

DOI:10.1023/a:1017609726742

PMID:11427900

Abstract

Systemic administration of ACTH to rats with normal hormone production induced a rapid (started 3 min postinjection) and long-term (persisted 30 min) elevation of pain threshold. Complete inhibition of glucocorticoid production shortened the duration of ACTH-induced analgesia to 15 min. The biphasic effect of ACTH on pain sensitivity is probably mediated by short-term glucocorticoid-independent and long-term glucocorticoid-dependent mechanisms.

摘要