类风湿关节炎中的核因子κB：炎症、增生及组织破坏的关键调节因子
NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction.
作者信息
Makarov S S
机构信息
Center for Inflammatory Disorders, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7280, USA.
出版信息
Arthritis Res. 2001;3(4):200-6. doi: 10.1186/ar300. Epub 2001 Mar 26.
Abstract
The transcription factor NF-kappa B has been well recognized as a pivotal regulator of inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad involvement of NF-kappa B in other aspects of RA pathology, including development of T helper 1 responses, activation, abnormal apoptosis and proliferation of RA fibroblast-like synovial cells, and differentiation and activation of bone resorbing activity of osteoclasts. In agreement with this, studies in animal models of RA have demonstrated the high therapeutic efficacy of specific inhibitors of NF-kappa B pathway, indicating the feasibility of anti-NF-kappa B therapy for human disease.
摘要
转录因子核因子-κB（NF-κB）已被公认为类风湿关节炎（RA）炎症的关键调节因子，但最近的研究进展表明，NF-κB广泛参与RA病理的其他方面，包括辅助性T细胞1反应的发展、RA成纤维样滑膜细胞的激活、异常凋亡和增殖，以及破骨细胞骨吸收活性的分化和激活。与此一致的是，在RA动物模型中的研究表明，NF-κB通路特异性抑制剂具有很高的治疗效果，这表明抗NF-κB疗法治疗人类疾病具有可行性。
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