阴离子聚合物对盐酸普萘洛尔从骨架片中释放的影响。

Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets.

作者信息

Takka S, Rajbhandari S, Sakr A

机构信息

Industrial Pharmacy Program, College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.

出版信息

Eur J Pharm Biopharm. 2001 Jul;52(1):75-82. doi: 10.1016/s0939-6411(01)00147-3.

DOI:10.1016/s0939-6411(01)00147-3

PMID:11438426

Abstract

Anionic polymers, namely Eudragit S, Eudragit L 100-55, and sodium carboxymethylcellulose, were incorporated into hydroxypropylmethylcellulose (HPMC K100M) to modify the drug release from HPMC matrices. The effects of changing the ratio of HPMC to anionic polymers were examined in water and in media with different pH. The dissolution profiles were compared according to release rates. The interaction between propranolol hydrochloride and anionic polymers was confirmed using the UV difference spectra method. The drug release was controlled with the type of anionic polymer and the interaction between propranolol hydrochloride and anionic polymers. The HPMC-anionic polymer ratio also influenced the drug release. The matrix containing HPMC-Eudragit L 100-55 (1:1 ratio) produced pH-independent extended-release tablets in water, 0.1 N HCl, and pH 6.8 phosphate buffer.

摘要

将阴离子聚合物，即尤特奇S、尤特奇L 100-55和羧甲基纤维素钠，加入羟丙基甲基纤维素（HPMC K100M）中，以改变药物从HPMC基质中的释放。在水和不同pH值的介质中研究了改变HPMC与阴离子聚合物比例的影响。根据释放速率比较了溶出曲线。采用紫外差示光谱法证实了盐酸普萘洛尔与阴离子聚合物之间的相互作用。药物释放受阴离子聚合物类型以及盐酸普萘洛尔与阴离子聚合物之间相互作用的控制。HPMC与阴离子聚合物的比例也影响药物释放。含有HPMC-尤特奇L 100-55（1:1比例）的基质在水、0.1 N盐酸和pH 6.8磷酸盐缓冲液中制备出了pH值无关的缓释片。