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产前乙型肝炎筛查——是否需要一项国家政策?

Antenatal hepatitis B screening - is there a need for a national policy?

作者信息

Healy C M, Cafferkey M T, Butler K M, Cahill I, McMorrow J, Philbin M, Beckett M, Mackey R, MacMathuna P, Dooley S, Hall W W, McKenna P

机构信息

Rotunda Hospital, Dublin.

出版信息

Ir Med J. 2001 Apr;94(4):111-2, 114.

Abstract

Routine antenatal testing for hepatitis B carriage with maternal consent was introduced at the Rotunda in January 1998. The uptake of testing has been excellent; 99.98% of women presenting for antenatal care accepted hepatitis B (HBV) screening in the 30-months from January 1998 through June 2000. The prevalence of HBV carriage was 0.35% (58 pregnancies of 16,222 tested) increasing from 0.25% in 1998 (16 of 6227) to 0.45% in the first six months of 2000 (16 of 3484). Fifty-five women had 58 pregnancies (three women had two pregnancies). Two of these were e-antigen positive. HBV carrier status was previously unknown in 48 (87%). Two additional women had acute HBV infection in pregnancy. Forty-five infants have been born to mothers included in this screening programme. Audit of infant outcome reveals excellent compliance with immunisation and follow-up: 29 (64%) have completed the 3 dose HBV vaccination schedule to date. Thirteen infants (31%) are still attending; three are lost to follow-up including one whose family has emigrated. Routine antenatal screening for hepatitis B carriage is cost-effective and should be considered a standard of care in maternity practice.

摘要

1998年1月,在罗通达医院经产妇同意后开展了常规产前乙型肝炎携带情况检测。检测的接受度非常高;在1998年1月至2000年6月的30个月中,99.98%前来接受产前护理的女性接受了乙型肝炎(HBV)筛查。HBV携带率为0.35%(在16222例受检妊娠中,有58例携带HBV),从1998年的0.25%(6227例中有16例)增至2000年前六个月的0.45%(3484例中有16例)。55名女性有58次妊娠(3名女性有两次妊娠)。其中两名是e抗原阳性。48名(87%)女性此前未知自己为HBV携带者。另有两名女性在孕期发生急性HBV感染。参与该筛查项目的母亲所生的婴儿已有45名。对婴儿结局的审查显示,免疫接种和随访的依从性良好:迄今为止,29名(64%)婴儿已完成3剂HBV疫苗接种程序。13名婴儿(31%)仍在接受随访;3名失访,其中1名婴儿的家人已移民。常规产前筛查HBV携带情况具有成本效益,应被视为产科实践中的一项护理标准。

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