Molecular physiology of renal p-aminohippurate secretion.
作者信息
Burckhardt G, Bahn A, Wolff N A
机构信息
Zentrum Physiologie und Pathophysiologie, Georg-August-Universität, 37073 Göttingen, Germany.
出版信息
News Physiol Sci. 2001 Jun;16:114-8. doi: 10.1152/physiologyonline.2001.16.3.114.
Abstract
Renal proximal tubules secrete various organic anions, including drugs and p-aminohippurate (PAH). Uptake of PAH from blood into tubule cells occurs by exchange with intracellular alpha-ketoglutarate and is mediated by the organic anion transporter 1. PAH exit into tubule lumen is species specific and may involve ATP-independent and -dependent transporters.
摘要
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