双侧丘脑底核刺激对帕金森步态的影响。

Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait.

作者信息

Stolze H, Klebe S, Poepping M, Lorenz D, Herzog J, Hamel W, Schrader B, Raethjen J, Wenzelburger R, Mehdorn H M, Deuschl G, Krack P

机构信息

Department of Neurology, Christian-Albrechts-Universität Kiel, Germany.

出版信息

Neurology. 2001 Jul 10;57(1):144-6. doi: 10.1212/wnl.57.1.144.

DOI:10.1212/wnl.57.1.144

PMID:11445647

Abstract

Gait analysis was carried out to assess the effects of L-dopa and bilateral subthalamic nucleus stimulation on gait velocity, cadence, stride length, and gait kinematics in nine patients with PD. Substantial effects of bilateral subthalamic nucleus stimulation on gait, with an increase in gait velocity and stride length comparable to that of a suprathreshold L-dopa dose, were found. Interestingly, stride length was more improved by L-dopa and cadence more by subthalamic nucleus stimulation. In two patients with freezing during the "on" period, subthalamic nucleus stimulation failed to reduce this symptom effectively.

摘要

对9例帕金森病患者进行步态分析，以评估左旋多巴和双侧丘脑底核刺激对步态速度、步频、步幅和步态运动学的影响。研究发现，双侧丘脑底核刺激对步态有显著影响，其步态速度和步幅的增加与超阈值左旋多巴剂量相当。有趣的是，左旋多巴对步幅的改善更大，而丘脑底核刺激对步频的改善更大。在2例“开”期出现冻结现象的患者中，丘脑底核刺激未能有效减轻这一症状。