两只患血吸虫病犬的甲状旁腺激素相关蛋白升高及高钙血症
Elevated parathyroid hormone-related protein and hypercalcemia in two dogs with schistosomiasis.
作者信息
Fradkin J M, Braniecki A M, Craig T M, Ramiro-Ibanez F, Rogers K S, Zoran D L
机构信息
Department of Small Animal Medicine, College of Veterinary Medicine, Texas A&M University, College Station 77843, USA.
出版信息
J Am Anim Hosp Assoc. 2001 Jul-Aug;37(4):349-55. doi: 10.5326/15473317-37-4-349.
Two adult dogs were evaluated for hypercalcemia. Diagnostic evaluation identified elevated parathyroid hormone-related protein (PTHrP) and presumptive humoral hypercalcemia of malignancy. At necropsy, schistosomiasis was diagnosed. North American schistosomiasis is caused by Heterobilharzia americana. Clinical findings may include dermatitis, coughing, diarrhea, and anorexia. Clinicopathological findings may include hypercalcemia, hyperglobulinemia, hypoalbuminemia, anemia, and eosinophilia. Diagnosis by fecal examination is difficult. Praziquantel or fenbendazole treatment may be curative or palliative. These are the first reported cases of hypercalcemia with elevated PTHrP in animals without diagnosed malignancy. Elevation of PTHrP has not been previously reported in hypercalcemic humans or in animals with granulomatous inflammation.
对两只成年犬进行了高钙血症评估。诊断性评估发现甲状旁腺激素相关蛋白（PTHrP）升高，推测为恶性肿瘤性体液性高钙血症。尸检时诊断为血吸虫病。北美血吸虫病由美洲异毕吸虫引起。临床症状可能包括皮炎、咳嗽、腹泻和厌食。临床病理表现可能包括高钙血症、球蛋白血症、低白蛋白血症、贫血和嗜酸性粒细胞增多。通过粪便检查进行诊断较为困难。吡喹酮或芬苯达唑治疗可能具有治愈或缓解作用。这些是首次报道的未诊断出恶性肿瘤的动物中PTHrP升高伴高钙血症的病例。此前尚未在高钙血症患者或患有肉芽肿性炎症的动物中报道过PTHrP升高的情况。
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