Bhisutthibhan J, Meshnick S R
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA.
Antimicrob Agents Chemother. 2001 Aug;45(8):2397-9. doi: 10.1128/AAC.45.8.2397-2399.2001.
Artemisinin and its derivatives are endoperoxide-containing antimalarial drugs that appear to form adducts in situ with the Plasmodium falciparum translationally controlled tumor protein (TCTP) homolog. Immunoprecipitation with antibody to recombinant TCTP suggests that adducts may form with both monomeric and dimeric TCTP.
青蒿素及其衍生物是含内过氧化物的抗疟药物,似乎能在原位与恶性疟原虫翻译控制肿瘤蛋白(TCTP)同源物形成加合物。用针对重组TCTP的抗体进行免疫沉淀表明,加合物可能与单体和二聚体TCTP均形成。