一种细菌将致癌物苯并[a]芘和苯并[a]蒽氧化为二氢二醇。
Oxidation of the carcinogens benzo [a] pyrene and benzo [a] anthracene to dihydrodiols by a bacterium.
作者信息
Gibson D T, Mahadevan V, Jerina D M, Yogi H, Yeh H J
出版信息
Science. 1975 Jul 25;189(4199):295-7. doi: 10.1126/science.1145203.
A mutant strain of Beijerinckia, after growth with succinate plus biphenyl, contains an enzyme system that oxidizes benzo [a] pyrene and benzo [a] anthracene to mixtures of vicinal dihydrodiols. The major dihydrodiol formed from benzo [a] pyrene was identified as cis-9, 10-dihydroxy-9, 10-dihydrobenzo [a] pyrene by comparison with a synthetic sample. Benzo [a] anthracene was metabolized to four dihydrodiols, the major isomer being cis-1, 2-dihydroxy-1, 2-dihydroxy-1, 2-dihydrobenzo [a] anthracene.
拜叶林克氏菌的一个突变菌株在以琥珀酸盐加联苯为培养基生长后，含有一种酶系统，该酶系统可将苯并[a]芘和苯并[a]蒽氧化为邻位二氢二醇的混合物。通过与合成样品比较，确定由苯并[a]芘形成的主要二氢二醇为顺式-9,10-二羟基-9,10-二氢苯并[a]芘。苯并[a]蒽被代谢为四种二氢二醇，主要异构体为顺式-1,2-二羟基-1,2-二氢苯并[a]蒽。
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