Cooper H M, Kennedy H, Magnin M, Vital-Durand F
J Comp Neurol. 1979 Sep 1;187(1):145-67. doi: 10.1002/cne.901870109.
Electrophysiological recording of single neurons was used to describe the representation of visual space in area 17, and the technique of retrograde transport of horseradish peroxidase (HRP) was applied to relate these results to projections from the thalamus in the prosimian primate Microcebus murinus. The visuotopic organization of area 17 was found to resemble that of other primates. On the dorsal surface, the border of area 17 corresponds to the representation of the vertical meridian. Proceeding medially across the surface the location of receptive fields descends along the vertical meridian, while moving caudally receptive fields progress temporally. Most of the dorsolateral surface is devoted to central vision and corresponds to a well developed area centralis. Following HRP injections in striate cortex, columns of labeled cells were found in the dorsal lateral geniculate (dLGN) extending orthogonally across all six layers. These columns run in a general ventrodorsal and caudorostral direction, parallel to a line connecting the cellular discontinuities corresponding to the optic disc. These discontinuities are present in magnocellular layer 1 and parvocellular layers 5 and 6, thus receiving from the nasal retina of the contralateral eye. The representation of the vertical meridian is situated in the ventromedial portion of the dLGN, and the monocular field is represented in the dorsal extremity. Anterior dLGN projects to the calcarine fissure (lower field) and posterior dLGN projects to the ventral surface of the cortex (upper field). Extrageniculate input to area 17 was found to originate from the pulvinar. HRP labeled cells were located in two distinct divisions of this nucleus, the cytoarchitecture of which is described. In addition, projections to occipital cortex were found to arise from the intralaminar nuclei.
通过对单个神经元进行电生理记录来描述17区视觉空间的表征，并应用辣根过氧化物酶（HRP）逆行运输技术，将这些结果与原猴亚目灵长类动物小鼠狐猴丘脑的投射联系起来。发现17区的视拓扑组织与其他灵长类动物相似。在背表面，17区的边界对应于垂直子午线的表征。沿着表面向内侧移动时，感受野的位置沿垂直子午线下降，而向尾侧移动时，感受野在时间上向前推进。背外侧表面的大部分区域用于中央视觉，对应于一个发育良好的中央凹区域。在纹状皮层注射HRP后，在背侧外侧膝状体（dLGN）中发现了标记细胞柱，这些柱垂直穿过所有六层。这些柱大致沿腹背和尾嘴方向延伸，平行于连接对应于视盘的细胞不连续处的线。这些不连续处存在于大细胞层1以及小细胞层5和6中，因此接收来自对侧眼鼻侧视网膜的信息。垂直子午线的表征位于dLGN的腹内侧部分，单眼视野则在背侧末端表示。dLGN前部投射到距状裂（下视野），后部投射到皮层腹表面（上视野）。发现17区的非膝状体输入起源于丘脑枕。HRP标记细胞位于该核的两个不同区域，并对其细胞结构进行了描述。此外，发现枕叶皮层的投射来自层内核。
