Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease.

作者信息

Nicosia F, Alberici A, Benussi L, Gasparini L, Ghidoni R, Mazzoli F, Zanetti O, Frisoni G B, Geroldi C, Binetti G

机构信息

Neurobiology Laboratory, Alzheimer's Unit, IRCCS Centro San Giovanni di Dio-Fatebenefratelli, Via Pilastroni 4, I-25123 Brescia, Italy.

出版信息

Dement Geriatr Cogn Disord. 2001 Sep-Oct;12(5):305-8. doi: 10.1159/000051274.

DOI:10.1159/000051274

PMID:11455130

Abstract

A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE epsilon4 status.

摘要