类胡萝卜素在芬顿反应中作为自由基清除剂：抗氧化剂还是促氧化剂？
Carotenoids as scavengers of free radicals in a Fenton reaction: antioxidants or pro-oxidants?
作者信息
Polyakov N E, Leshina T V, Konovalova T A, Kispert L D
机构信息
Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia.
出版信息
Free Radic Biol Med. 2001 Aug 1;31(3):398-404. doi: 10.1016/s0891-5849(01)00598-6.
The spin trapping EPR technique was used to study the influence of carotenoids (beta-carotene, 8'-apo-beta-caroten-8'-al, canthaxanthin, and ethyl 8'-apo-beta-caroten-8'-oate) on the yield of free radicals in the Fenton reaction (Fe(2+) + H(2)O(2) --> Fe(3+) + .OH + -OH) in the organic solvents, DMSO, and methanol. DMPO and PBN were used as spin trapping agents. It was demonstrated that carotenoids could increase or decrease the total yield of free radicals depending on the oxidation potential of the carotenoids and the nature of the radicals. A reaction mechanism is suggested which includes the reduction of Fe(3+) to Fe(2+) by carotenoids. The effectiveness of this carotenoid-driven Fenton reaction increases with a decrease of the scavenging rates for free radicals and with decreasing oxidation potentials of carotenoids.
自旋捕集电子顺磁共振技术被用于研究类胡萝卜素（β-胡萝卜素、8'-阿朴-β-胡萝卜素-8'-醛、角黄素和8'-阿朴-β-胡萝卜素-8'-乙酯）对有机溶剂二甲基亚砜（DMSO）和甲醇中芬顿反应（Fe(2+) + H(2)O(2) --> Fe(3+) + ·OH + -OH）中自由基产率的影响。二甲基哌啶氧化物（DMPO）和苯基叔丁基硝酮（PBN）被用作自旋捕集剂。结果表明，根据类胡萝卜素的氧化电位和自由基的性质，类胡萝卜素可以增加或降低自由基的总产率。提出了一种反应机制，其中包括类胡萝卜素将Fe(3+)还原为Fe(2+)。这种由类胡萝卜素驱动的芬顿反应的有效性随着自由基清除率的降低和类胡萝卜素氧化电位的降低而增加。
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