Schilling F H, Ambros P F, Bihl H, Martinsson T, Ambros I M, Borgström P, Jacobsson H, Falkmer U G, Treuner J, Kogner P
Oncology/Hematology/Immunology, Olgahospital, Childhood and Adolescent Health, Stuttgart, Germany. fhs.nbs.s.shuttle.de
Med Pediatr Oncol. 2001 Jan;36(1):56-60. doi: 10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1.
Poor prognosis in childhood neuroblastoma is associated with deletions of chromosome region 1p36 and di/tetraploid DNA content.
Forty-six patients with histopathologically proven neuroblastoma were investigated for in vivo expression of somatostatin receptors (SR) by 111In-pentetreotide scintigraphy. All tumors were analyzed for cytometric DNA content and chromosome 1p36 integrity.
SR expression was detected in 28 tumors (61%) and correlated with young age, localized clinical stage, and favorable outcome. Fourteen tumors showed deletion at chromosome 1p36, thirteen of which did not show SR expression (P< 0.001). A triploid DNA content was correlated with the presence of SR (23 of 25, P< 0.001). No tumor with deletion of chromosome 1p36 and di/tetra DNA content showed SR expression (chi2 = 29.88, d.o.f. = 2, P < 0.001).
We conclude that SR expression is related to genetic features of prognostic significance. This may be assessed with a minimally invasive scintigraphic method.
Zotero 插件