庚型肝炎病毒致病性的初步研究
Preliminary study on pathogenicity of hepatitis G virus.
作者信息
Liao S, Zhan M, Yang Z
机构信息
Department of Digestion, Tiantan Affiliated Hospital of Capital University of Medical Sciences, Beijing 100050, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2000 Dec;14(4):358-60.
OBJECTIVE
To study the clinical, enzymatic and liver pathological changes in patients with hepatitis G virus (HGV) infection.
METHODS
RT- nested PCR was applied to detect HGV RNA in 368 patients with hepatic diseases. The liver biopsy tissue from one liver cirrhosis patient with simple HGV infection was examined.
RESULTS
Simple HGV RNA positive were found in 7 cases of 71 acute hepatitis jaundice, in 22 cases of 155 chronic hepatitis and in 3 cases of 51 liver cirrhosis. The immunohistochemistry of the liver biopsy tissue from a liver cirrhosis patient showed HGV NS5 antigen positive. However, HGV infection might occur simply or in combination with hepatitis B or C virus or super infected.
CONCLUSIONS
HGV RNA could be detected in acute hepatitis jaundice, chronic hepatitis, hepatitis B or C carriers, liver cirrhosis and hepatocellular carcinoma. HGV is proved to be a hepatotropic virus by pathological examination and immunohistochemistry, the virus located in the cytoplasm of the liver cells. It may cause chronic hepatitis and even liver cirrhosis, so HGV is pathogenic to liver tissue.
目的
研究庚型肝炎病毒（HGV）感染患者的临床、酶学及肝脏病理变化。
方法
应用逆转录巢式聚合酶链反应（RT-巢式PCR）检测368例肝病患者的HGV RNA。对1例单纯HGV感染的肝硬化患者的肝活检组织进行检查。
结果
71例急性黄疸型肝炎患者中有7例单纯HGV RNA阳性，155例慢性肝炎患者中有22例，51例肝硬化患者中有3例。1例肝硬化患者肝活检组织的免疫组化显示HGV NS5抗原阳性。然而，HGV感染可能单独发生，或与乙型或丙型肝炎病毒合并发生或重叠感染。
结论
在急性黄疸型肝炎、慢性肝炎、乙型或丙型肝炎携带者、肝硬化及肝细胞癌患者中均可检测到HGV RNA。通过病理检查和免疫组化证明HGV是一种嗜肝病毒，该病毒位于肝细胞的细胞质中。它可能导致慢性肝炎甚至肝硬化，因此HGV对肝脏组织具有致病性。
Zotero 插件