Syrjänen R K, Kilpi T M, Kaijalainen T H, Herva E E, Takala A K
Department of Vaccines, National Public Health Institute (KTL), Helsinki, Finland.
J Infect Dis. 2001 Aug 15;184(4):451-9. doi: 10.1086/322048. Epub 2001 Jul 6.
To describe the natural course of nasopharyngeal carriage of Streptococcus pneumoniae and its relationship to acute otitis media (AOM), 329 Finnish children were followed from ages 2 to 24 months. In total, 3024 nasopharyngeal (NP) swabs (obtained at 10 scheduled healthy visits) and 2007 NP aspirates (obtained during respiratory infections) were cultured. Carriage during health increased gradually (9%-43%) with age. Within 4 age intervals, carriage was lower during health (13%-43%) than during respiratory infection without AOM (22%-45%). Higher proportions of positive samples were found during AOM (45%-56%), in particular during pneumococcal AOM (97%-100%). Antimicrobial treatment reduced carriage only temporarily. The most frequent NP serotypes were 6B, 6A, 11, 19F, and 23F. Both age and health status were important determinants of NP carriage of S. pneumoniae and these features should be considered carefully during analysis of carriage rates.
为描述肺炎链球菌鼻咽部携带的自然病程及其与急性中耳炎（AOM）的关系，对329名芬兰儿童从2个月至24个月进行了随访。共培养了3024份鼻咽（NP）拭子（在10次定期健康检查时采集）和2007份NP抽吸物（在呼吸道感染期间采集）。健康状态下的携带率随年龄逐渐增加（9% - 43%）。在4个年龄区间内，健康状态下的携带率（13% - 43%）低于无AOM的呼吸道感染期间（22% - 45%）。AOM期间（45% - 56%），尤其是肺炎球菌性AOM期间（97% - 100%），阳性样本比例更高。抗菌治疗仅能暂时降低携带率。最常见的NP血清型为6B、6A、11、19F和23F。年龄和健康状态都是肺炎链球菌NP携带的重要决定因素，在分析携带率时应仔细考虑这些特征。
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