核因子-κB参与阿片类物质戒断反应的表达。
Involvement of nuclear factor-kB in the expression of opiate withdrawal.
作者信息
Capasso A
机构信息
Department of Pharmaceutical Sciences, University of Salerno, Italy.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2001 Aug;25(6):1259-68. doi: 10.1016/s0278-5846(01)00178-6.
Abstract
- To investigate the role of NF-kB in the expression of opiate withdrawal, the effects of PDTC, an inhibitor of NF-kB activation, was studied on acute opiate withdrawal induced by morphine in vitro. 2. After a 4 min in vitro exposure to morphine, a strong contracture of guinea pig isolated ileum was observed after the addition of naloxone. 3. PDTC (1x10(-8)-5x10(-8)-1x10(-7) M) was able to reduce the naloxone-induced contracture after exposure to the opioid agonist in a concentration-dependent fashion. 4. The results of the present study indicate that NF-kB is involved in the expression of opiate withdrawal thus extending and explaining previous papers performed with dexamethasone and selective arachidonic acid metabolites inhibitors.
摘要
- 为研究核因子-κB（NF-κB）在阿片类药物戒断表达中的作用，研究了NF-κB激活抑制剂吡咯烷二硫代氨基甲酸盐（PDTC）对吗啡诱导的急性阿片类药物体外戒断的影响。2. 在体外暴露于吗啡4分钟后，加入纳洛酮后观察到豚鼠离体回肠强烈收缩。3. PDTC（1×10⁻⁸ - 5×10⁻⁸ - 1×10⁻⁷ M）能够以浓度依赖的方式降低暴露于阿片类激动剂后纳洛酮诱导的收缩。4. 本研究结果表明，NF-κB参与阿片类药物戒断的表达，从而扩展并解释了先前使用地塞米松和选择性花生四烯酸代谢物抑制剂进行的研究。
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