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爆发间期对自由活动成年雄性大鼠海马长时程增强指标的影响。

The effect of interburst intervals on measures of hippocampal LTP in the freely moving adult male rat.

作者信息

Fortin D A, Bronzino J D

机构信息

Department of Engineering, Trinity College, Hartford, Connecticut 06106-3100, USA.

出版信息

Exp Neurol. 2001 Aug;170(2):371-4. doi: 10.1006/exnr.2001.7713.

Abstract

An important factor in the induction and maintenance of long-term potentiation (LTP) is the tetanization paradigm. This paper presents the changes associated with the induction and maintenance of hippocampal LTP in the freely moving adult male rat, subjected to three different tetanization paradigms. These results indicate that specific LTP measures including (1) synaptic activation, as measured by the slope of the dentate granule cell population excitatory postsynaptic potential, and (2) cellular response, as measured by the dentate population spike amplitude, evoked by single-pulse stimulation of the medial perforant pathway are dependent on the interburst interval of the bursting paradigm commonly used in LTP studies.

摘要

强直刺激模式是诱导和维持长时程增强(LTP)的一个重要因素。本文呈现了自由活动的成年雄性大鼠在经历三种不同强直刺激模式后,海马LTP诱导和维持过程中相关的变化。这些结果表明,特定的LTP指标包括:(1)突触激活,通过齿状颗粒细胞群体兴奋性突触后电位的斜率来衡量;(2)细胞反应,通过内侧穿通通路单脉冲刺激诱发的齿状群体峰电位幅度来衡量,这些指标取决于LTP研究中常用的爆发模式的脉冲间隔。

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