Tucci A, Poli L, Biasco G, Paparo G F, Tosetti C, Fusaroli P, Sambri V, Donati M, Grigioni W, Labate A M, Stanghellini V, Caletti G
Department of Internal Medicine and Gastroenterology, Hospital S. Orsola-Malpighi, University of Bologna, Italy.
Dig Dis Sci. 2001 Jul;46(7):1573-83. doi: 10.1023/a:1010668727340.
In the present study we evaluated the relation among histology, H. pylori, IgG to H. pylori, gastric emptying, and acid secretion in 43 patients with fundic atrophic gastritis. On the basis of gastric acid secretion, patients were divided into three subgroups: patients with preserved acid secretion (Group 1), patients with hypochlorhydria (Group 2), and patients with achlorhydria (Group 3). Fundic glandular atrophy was more severe in hypoachlorhydric patients than in those with preserved acid secretion (P < 0.05 vs Group 2, P < 0.005 vs Group 3). H. pylori colonization was found in 94% of patients in Group 1, in 61% of patients in Group 2, and in only 8% of patients in Group 3 (P < 0.001 vs Group 1, P < 0.05 vs Group 2). Conversely, serological positivity to H. pylori was high in all three subgroups of patients (100% in Group 1, 77% in Group 2, 92% in Group 3). Gastric emptying was delayed in atrophic patients, particularly in those with hypoachlorhydria. Our data suggest that fundic atrophic gastritis represents a possible end stage of H. pylori infection, characterized by a progressive disappearance of the bacterium and a progressive deterioration of gastric functions.
在本研究中，我们评估了43例胃底萎缩性胃炎患者的组织学、幽门螺杆菌、幽门螺杆菌IgG、胃排空和胃酸分泌之间的关系。根据胃酸分泌情况，患者被分为三个亚组：胃酸分泌正常的患者（第1组）、胃酸过少的患者（第2组）和无胃酸分泌的患者（第3组）。胃酸过少患者的胃底腺萎缩比胃酸分泌正常的患者更严重（与第2组相比P<0.05，与第3组相比P<0.005）。第1组94%的患者、第2组61%的患者和第3组仅8%的患者发现有幽门螺杆菌定植（与第1组相比P<0.001，与第2组相比P<0.05）。相反，三组患者的幽门螺杆菌血清学阳性率均较高（第1组为100%，第2组为77%，第3组为92%）。萎缩性胃炎患者的胃排空延迟，尤其是胃酸过少的患者。我们的数据表明，胃底萎缩性胃炎可能是幽门螺杆菌感染的终末阶段，其特征是细菌逐渐消失和胃功能逐渐恶化。
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