Davis I, Matalon S
Department of Comparative Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35233-6810, USA.
News Physiol Sci. 2001 Aug;16:185-90. doi: 10.1152/physiologyonline.2001.16.4.185.
Recent evidence suggests that pneumonitis induced by many important human viral pathogens may result from exuberant generation of reactive species by inflammatory cells in response to infection. This review summarizes current evidence from animal model studies regarding the beneficial (antiviral) and harmful (tissue-damaging) effects of reactive species for the host.
近期证据表明,许多重要人类病毒病原体引发的肺炎可能是炎症细胞针对感染产生过量反应性物质所致。本综述总结了来自动物模型研究的当前证据,这些证据涉及反应性物质对宿主的有益(抗病毒)和有害(组织损伤)作用。