[粘性放线菌对牙齿的粘附研究。IV. 粘性放线菌唾液蛋白受体的研究]

[The study of actinomyces viscosus adhere to teeth. IV. The study of salivary protein receptors of A. viscosus].

作者信息

Zhao L, Liu T, Yue S

机构信息

College of Stomatology, West China University of Medical Sciences.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 1997 Feb;15(1):58-60.

PMID:11480063

Abstract

In order to determine the receptors of A. viscosus for adhesion, 7 kinds of main purified proteins from pellicle formed by whole saliva were tested. The result indicated that: 1. APRP, statherin, PRPG and SIgA were the receptors of standard and fresh isolated A. viscosus; 2. APRP and stather promoted the adherence of 5519 (1+2-) to HA, and SIgA promoted the adherence 5951 (1-2+) to HA; PRPG was the common receptor of the two fimbriae. It suggested that there were receptors not only type 1 fimbriae but also type 2 in pellicle. Two types of fimbriae were involved in the adherence of A. viscosus to pellicle. The difference existed in the receptor of adherence and the activity site of the same receptor.

摘要

为了确定粘性放线菌的粘附受体，对全唾液形成的薄膜中的7种主要纯化蛋白进行了测试。结果表明：1. 富脯蛋白（APRP）、唾液蛋白、富含脯氨酸的磷蛋白（PRPG）和分泌型免疫球蛋白A（SIgA）是标准株和新鲜分离的粘性放线菌的受体；2. APRP和唾液蛋白促进5519（1+2-）对羟基磷灰石（HA）的粘附，SIgA促进5951（1-2+）对HA的粘附；PRPG是两种菌毛的共同受体。这表明薄膜中不仅存在1型菌毛的受体，也存在2型菌毛的受体。两种类型的菌毛都参与了粘性放线菌对薄膜的粘附。在粘附受体和同一受体的活性位点上存在差异。