Mayr B, Montminy M
Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609. doi: 10.1038/35085068.
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?
转录因子CREB（即“环磷酸腺苷反应元件结合蛋白”）在葡萄糖稳态、生长因子依赖性细胞存活中发挥作用，并且与学习和记忆有关。CREB会响应各种信号而发生磷酸化，但这些信号通路是如何实现特异性的呢？
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