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氟奋乃静对组织去甲肾上腺素浓度的影响及其与帕吉林的相互作用。

Effect of fluphenazine on tissue noradrenaline concentrations and its interaction with pargyline.

作者信息

Azhary R A, Khayyal M T, Saleh S

出版信息

Br J Pharmacol. 1975 Apr;53(4):593-5. doi: 10.1111/j.1476-5381.1975.tb07399.x.

DOI:10.1111/j.1476-5381.1975.tb07399.x
PMID:1148501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666309/
Abstract

Fluphenazine caused a small decrease in the noradrenaline (NA) concentrations of the rat brain, possibly by impairing granular amine storage. The drug diminished the rise in brain and heart NA concentrations induced by pargyline, suggesting that it might posses inhibitory properties on neuronal uptake mechanisms and/or NA synthesis. Fluphenazine abolished conditioned avoidance responses in rats, an effect which was maintained after the concomitant administration of pargyline, when NA concentrations remained high. This suggests that the fluphenazine-induced sedation is not mediated via its effect on brain NA content, but is possibly due to the effect of the drug on NA turnover rates in the brain.

摘要

氟奋乃静导致大鼠脑内去甲肾上腺素（NA）浓度略有下降，可能是通过损害颗粒胺储存来实现的。该药物减弱了优降宁诱导的脑和心脏NA浓度升高，这表明它可能对神经元摄取机制和/或NA合成具有抑制特性。氟奋乃静消除了大鼠的条件性回避反应，当NA浓度仍然很高时，在同时给予优降宁后这种效应依然存在。这表明氟奋乃静诱导的镇静作用不是通过其对脑内NA含量的影响来介导的，而是可能归因于该药物对脑内NA周转率的影响。

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