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Br J Pharmacol. 1975 Apr;53(4):593-5. doi: 10.1111/j.1476-5381.1975.tb07399.x.
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本文引用的文献

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EFFECTS OF CHLORPROMAZINE ON THE METABOLISM OF DL-2-C14-DOPA IN THE RAT.
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A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
3
Relation between norepinephrine accumulation or depletion and blood pressure responses in the cat and rat following pargyline administration.帕吉林给药后猫和大鼠体内去甲肾上腺素蓄积或耗竭与血压反应之间的关系。
Ann N Y Acad Sci. 1963 Jul 8;107:924-34. doi: 10.1111/j.1749-6632.1963.tb13335.x.
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Influence of chlorpromazine and chlorprothixene on the cerebral metabolism of 5-hydroxytryptamine, norepinephrine and dopamine.氯丙嗪和氯普噻吨对5-羟色胺、去甲肾上腺素和多巴胺脑代谢的影响。
J Pharmacol Exp Ther. 1961 Jul;133:18-24.
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Behavioral effects of some psychopharmacological agents.一些精神药理药物的行为效应。
Ann N Y Acad Sci. 1957 Mar 14;66(3):740-52. doi: 10.1111/j.1749-6632.1957.tb40763.x.
6
The effects of psychoactive drugs on norepinephrine-3-H metabolism in brain.精神活性药物对大脑中去甲肾上腺素-3-H代谢的影响。
Biochem Pharmacol. 1967 Feb;16(2):393-9. doi: 10.1016/0006-2952(67)90040-8.
7
Antagonism by monoamine oxidase inhibitors of alpha-methyltyrosine-induced catecholamine depletion and behavioral depression.单胺氧化酶抑制剂对α-甲基酪氨酸诱导的儿茶酚胺耗竭及行为性抑郁的拮抗作用。
J Pharmacol Exp Ther. 1967 Apr;156(1):70-5.
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Monoamine oxidase inhibitors.单胺氧化酶抑制剂
Pharmacol Rev. 1966 Mar;18(1):121-9.
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The catecholamine hypothesis of affective disorders: a review of supporting evidence.情感障碍的儿茶酚胺假说：支持证据综述
Am J Psychiatry. 1965 Nov;122(5):509-22. doi: 10.1176/ajp.122.5.509.
10
The comparative effectiveness of eight phenothiazines.八种吩噻嗪类药物的比较疗效
Psychopharmacologia. 1965 Feb 15;7(2):89-106. doi: 10.1007/BF00403632.

氟奋乃静对组织去甲肾上腺素浓度的影响及其与帕吉林的相互作用。

Effect of fluphenazine on tissue noradrenaline concentrations and its interaction with pargyline.

作者信息

Azhary R A, Khayyal M T, Saleh S

出版信息

Br J Pharmacol. 1975 Apr;53(4):593-5. doi: 10.1111/j.1476-5381.1975.tb07399.x.

DOI:10.1111/j.1476-5381.1975.tb07399.x
PMID:1148501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666309/
Abstract

Fluphenazine caused a small decrease in the noradrenaline (NA) concentrations of the rat brain, possibly by impairing granular amine storage. The drug diminished the rise in brain and heart NA concentrations induced by pargyline, suggesting that it might posses inhibitory properties on neuronal uptake mechanisms and/or NA synthesis. Fluphenazine abolished conditioned avoidance responses in rats, an effect which was maintained after the concomitant administration of pargyline, when NA concentrations remained high. This suggests that the fluphenazine-induced sedation is not mediated via its effect on brain NA content, but is possibly due to the effect of the drug on NA turnover rates in the brain.

摘要

氟奋乃静导致大鼠脑内去甲肾上腺素（NA）浓度略有下降，可能是通过损害颗粒胺储存来实现的。该药物减弱了优降宁诱导的脑和心脏NA浓度升高，这表明它可能对神经元摄取机制和/或NA合成具有抑制特性。氟奋乃静消除了大鼠的条件性回避反应，当NA浓度仍然很高时，在同时给予优降宁后这种效应依然存在。这表明氟奋乃静诱导的镇静作用不是通过其对脑内NA含量的影响来介导的，而是可能归因于该药物对脑内NA周转率的影响。