对一名患有与严重腋窝多汗症相关肌肉痉挛的患者进行肉毒杆菌A毒素腋窝注射。

Axillary injection of botulinum A toxin in a patient with muscle cramps associated with severe axillary hyperhidrosis.

作者信息

Filosto M, Bertolasi L, Fincati E, Priori A, Tomelleri G, Chieregato G, Rizzuto N

机构信息

Department of Neurological Sciences and Vision, Section of Clinical Neurology, University of Verona, Italy.

出版信息

Acta Neurol Belg. 2001 Jun;101(2):121-3.

PMID:11486559

Abstract

Muscle cramps may be caused by fluid and salt loss induced by diffuse or focal hyperhidrosis. Recent reports have described the efficacy of botulinum, toxin in the treatment of primary focal hyperhidrosis. Botulinum toxin inhibits sweating by blocking exocytosis of acetylcholine from presynaptic cholinergic nerve terminals. We report the case of a patient who complained of frequent muscle cramps associated with unusually severe axillary hyperhidrosis. We used botulinum toxin to treat the excessive focal sweating presuming that it would also reduce the muscle cramps. A total dose of 200 MU of botulinum A toxin (Dysport) per axilla markedly reduced sweating and cramps. The beneficial effect started four days after the injection and it was still present five months later. Treatment was repeated in the sixth month with analogous results. No side-effects were observed and no compensatory sweating occurred.

摘要

肌肉痉挛可能由弥漫性或局灶性多汗症导致的体液和盐分流失引起。最近的报告描述了肉毒杆菌毒素在治疗原发性局灶性多汗症方面的疗效。肉毒杆菌毒素通过阻断乙酰胆碱从突触前胆碱能神经末梢的胞吐作用来抑制出汗。我们报告了一例患者，该患者抱怨频繁出现肌肉痉挛，并伴有异常严重的腋窝多汗症。我们使用肉毒杆菌毒素治疗局部多汗症，推测这也会减轻肌肉痉挛。每侧腋窝注射总量为200 MU的A型肉毒杆菌毒素（Dysport）可显著减少出汗和痉挛。有益效果在注射后四天开始出现，五个月后仍然存在。在第六个月重复治疗，结果类似。未观察到副作用，也未出现代偿性出汗。