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前列腺癌的免疫疗法。

Immunotherapy for prostate cancer.

作者信息

Rini B I, Small E J

机构信息

University of California at San Francisco Comprehensive Cancer Center, 1600 Divisidero Street, 3rd floor, San Francisco, CA 94115, USA.

出版信息

Curr Oncol Rep. 2001 Sep;3(5):418-23. doi: 10.1007/s11912-001-0028-1.

Abstract

The components of an effective immune response have been elucidated in recent years. An understanding of the dysfunction of the immune response in cancer in one or more of these components has led to a variety of immunotherapeutic approaches. These therapeutic strategies are designed to stimulate dendritic cell proliferation, promote antigen uptake and processing, stimulate an effector cell response via direct antigen presentation, or target tumor cells via antibody therapy. Many approaches in prostate cancer have demonstrated successful induction of the desired immune response. Limited clinical success has also been seen.

摘要

近年来,有效免疫反应的组成部分已得到阐明。对癌症中免疫反应在这些组成部分中的一个或多个方面功能障碍的理解,催生了多种免疫治疗方法。这些治疗策略旨在刺激树突状细胞增殖、促进抗原摄取和加工、通过直接抗原呈递刺激效应细胞反应,或通过抗体疗法靶向肿瘤细胞。前列腺癌的许多方法已证明成功诱导了所需的免疫反应。但临床成功也有限。

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