Hori T, Matsubara T, Ishibashi T, Higuchi K, Ochiai S, Takemoto M, Imai S, Nakagawa I, Ozaki K, Hatada K, Mezaki T, Tsuchida K, Nasuno A, Nishio M, Aizawa Y
First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1-754, Niigata, Niigata 951-8510.
J Cardiol. 2001 Jul;38(1):21-8.
Endothelial function in the brachial arteries is impaired in smokers. However, little is known about this condition in young adult men. The relationship between nitric oxide(NO) production and the endothelial function was investigated in young smokers and compared with non-smokers.
Flow-mediated vasodilation of the brachial artery during reactive hyperemia was examined in 10 young smokers(mean age 31 years) and 12 control subjects(mean age 28 years). The vasodilator response in the brachial artery was measured by ultrasonography, and blood samples were obtained from the right cephalic vein. Blood samples were taken at baseline, 30 sec after cuff deflation, and before and 5 min after 0.3 mg of nitroglycerin administration. Blood flow was calculated by multiplying mean flow velocity and vessel cross-sectional area. Plasma NOx(nitrate + nitrite) levels were measured, and the percentage change of NOx production(delta NOx) was calculated as follows: delta NOx(%) = [(NOx concentration at peak flow-mediated vasodilation or after 0.3 mg nitroglycerin administration) - baseline NOx concentration)] x 100/baseline NOx concentration.
Percentage changes in diameter of the brachial artery, NOx production and delta NOx in response to nitroglycerin were not statistically different between the two groups(smokers: 27.6 +/- 8.0 mumol/l, control subjects: 34.0 +/- 8.7 mumol/l). However, percentage change of flow-mediated vasodilation during reactive hyperemia in the young smokers was significantly smaller than that in the control subjects(4.8 +/- 2.7%, 9.1 +/- 5.3%, respectively, p < 0.05). Moreover, delta NOx during reactive hyperemia in the smokers was significantly smaller than that in the control subjects(388.8 +/- 90.2%, 738.0 +/- 284.5%, respectively, p < 0.05).
The impaired response to reactive hyperemia in young smokers might be associated with decreases in flow-dependent NO production.
吸烟者肱动脉的内皮功能受损。然而，对于年轻成年男性的这种情况知之甚少。研究了年轻吸烟者一氧化氮（NO）生成与内皮功能之间的关系，并与不吸烟者进行比较。
对10名年轻吸烟者（平均年龄31岁）和12名对照者（平均年龄28岁）进行反应性充血期间肱动脉的血流介导的血管舒张检查。通过超声检查测量肱动脉的血管舒张反应，并从右侧头静脉采集血样。在基线、袖带放气后30秒、给予0.3毫克硝酸甘油之前和之后5分钟采集血样。通过将平均流速与血管横截面积相乘来计算血流量。测量血浆NOx（硝酸盐+亚硝酸盐）水平，并按以下方式计算NOx生成的百分比变化（δNOx）：δNOx（%）=[（血流介导的血管舒张峰值或给予0.3毫克硝酸甘油后NOx浓度）-基线NOx浓度]×100/基线NOx浓度。
两组之间（吸烟者：27.6±8.0μmol/L，对照者：34.0±8.7μmol/L），肱动脉直径、NOx生成以及对硝酸甘油的δNOx的百分比变化无统计学差异。然而，年轻吸烟者在反应性充血期间血流介导的血管舒张的百分比变化显著小于对照者（分别为4.8±2.7%和9.1±5.3%，p<0.05）。此外，吸烟者在反应性充血期间的δNOx显著小于对照者（分别为388.8±90.2%和738.0±284.5%，p<0.05）。
年轻吸烟者对反应性充血的反应受损可能与血流依赖性NO生成减少有关。
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