成人T细胞白血病/淋巴瘤累及十二指肠的临床及内镜特征

Clinical and endoscopic features of adult T-cell leukemia/lymphoma with duodenal involvement.

作者信息

Isomoto H, Ohnita K, Mizuta Y, Maeda T, Onizuka Y, Miyazaki M, Omagari K, Takeshima F, Murase K, Haraguchi M, Murata I, Kohno S

机构信息

Second Department of Internal Medicine, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan.

出版信息

J Clin Gastroenterol. 2001 Sep;33(3):241-6. doi: 10.1097/00004836-200109000-00017.

DOI:10.1097/00004836-200109000-00017

PMID:11500618

Abstract

We describe three cases of adult T-cell leukemia/lymphoma (ATLL) with duodenal involvement and provide a review of the literature. The first case, a 74-year-old woman with acute subtype of ATLL, had multiple polypoid lesions from the bulbus extending into the descending portion of the duodenum. The second case, a 70-year-old man with lymphoma subtype of ATLL, had a polypoid tumor in the descending portion of the duodenum and multiple protruded lesions in the small and large intestines. The third case, a 67-year-old man with lymphoma subtype of ATLL, had a flat-elevated lesion in the descending portion of the duodenum, as well as a gastric ulcerated lesion. Biopsies from these lesions showed mucosal invasion of ATLL cells in each case. All patients received combination chemotherapy, which was successful in the first and third cases, accompanied by the disappearance of gastroduodenal lesions.

摘要

我们描述了3例累及十二指肠的成人T细胞白血病/淋巴瘤（ATLL）病例，并对相关文献进行了综述。第一例为一名74岁患有急性亚型ATLL的女性，十二指肠球部有多个息肉样病变并延伸至降部。第二例为一名70岁患有淋巴瘤亚型ATLL的男性，十二指肠降部有一个息肉样肿瘤，小肠和大肠有多个突出病变。第三例为一名67岁患有淋巴瘤亚型ATLL的男性，十二指肠降部有一个扁平隆起病变以及一个胃溃疡病变。这些病变的活检在每例中均显示有ATLL细胞的黏膜浸润。所有患者均接受了联合化疗，第一例和第三例化疗成功，胃十二指肠病变消失。