5-羟色胺（5-HT）4受体拮抗剂SB-207266的代谢产物的合成与药理活性。
Synthesis and pharmacological activity of metabolites of the 5-HT(4) receptor antagonist SB-207266.
作者信息
Fedouloff M, Hossner F, Voyle M, Ranson J, Powles J, Riley G, Sanger G
机构信息
Department of Synthetic Chemistry, Smithkline Beecham Pharmaceuticals, New Frontiers Science Park, Essex CM19 5AW, Harlow, UK.
出版信息
Bioorg Med Chem. 2001 Aug;9(8):2119-28. doi: 10.1016/s0968-0896(01)00120-1.
Abstract
Three metabolites of N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]-oxazino[3,2_a]indole-10-carboxamide (SB-207266) (1) were synthesised and their pharmacological activity determined.
摘要
合成了N-[(1-丁基-4-哌啶基)甲基]-3,4-二氢-2H-[1,3]恶嗪并[3,2_a]吲哚-10-甲酰胺（SB-207266）（1）的三种代谢物，并测定了它们的药理活性。
Zotero 插件