[α干扰素治疗慢性乙型肝炎肝纤维化的血清标志物及病理评估]

[Serum markers and pathological evaluation in hepatitis fibrosis of chronic hepatitis B treated with interferon alpha].

作者信息

Deng L, Zhou Y, Peng X, Deng H, Deng Y, Yao J

机构信息

Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510630, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2001 Jul;9 Suppl:66-7.

PMID:11509145

Abstract

OBJECTIVE

To evaluate the anti-fibrotic effect of interferon alpha and to study the relationship between the anti-fibrotic effect and the efficacy of anti-virus in patients with chronic hepatitis B treated with interferon alpha.

METHODS

Thirty-six patients with chronic hepatitis B were treated with interferon alpha. Before, during and after the treatment, the levels of hyaluronic acid (HA), type III procollagen (PC-III), type IV collagen(IV-C), laminin (LN) and transforming growth factor beta 1 (TGF-beta 1) were measured as the markers of hepatic fibrosis. Needle biopsy sections of the liver taken before and at the end of IFN treatment were assessed and compared according to the modified histological activity index (HAI) and hepatic fibrosis (HF) scoring system.

RESULTS

In IFN group, the levels of HA, PC-III, IV-C, LN, and TGF-beta 1 after treatment were all significantly lower than those before treatment (P<0.01). The levels of HA, PC-III, and TGF-beta 1 after treatment were significantly lower in IFN group than in control one. HAI scores decreased from 9.3+/-3.2 to 6.2 +/-2.1 and HF scores decreased from 7.5+/-2.2 to 5.1+/-1.8 after treatment.

CONCLUSIONS

The improvement of hepatic fibrosis closely related to the efficacy of anti-virus. Interferon alpha therapy is effective for hepatic fibrosis of chronic hepatitis B.

摘要

目的

评估α干扰素的抗纤维化作用，并研究α干扰素治疗慢性乙型肝炎患者时抗纤维化作用与抗病毒疗效之间的关系。

方法

36例慢性乙型肝炎患者接受α干扰素治疗。在治疗前、治疗期间及治疗后，检测透明质酸（HA）、Ⅲ型前胶原（PC-Ⅲ）、Ⅳ型胶原（Ⅳ-C）、层粘连蛋白（LN）和转化生长因子β1（TGF-β1）水平作为肝纤维化标志物。根据改良的组织学活动指数（HAI）和肝纤维化（HF）评分系统，对干扰素治疗前及治疗结束时所取肝穿刺活检切片进行评估和比较。