薄荷（Mentha piperita Linn.）对瑞士白化小鼠血清磷酸酶活性抗γ辐射的调节作用。

Modulatory effect of Mentha piperita (Linn.) on serum phosphatases activity in Swiss albino mice against gamma irradiation.

作者信息

Samarth R M, Goyal P K, Kumar A

机构信息

Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India.

出版信息

Indian J Exp Biol. 2001 May;39(5):479-82.

PMID:11510134

Abstract

Mentha extract (ME; 1 g/kg body wt) given orally for three consecutive days prior to whole body irradiation (8 Gy) showed modulation of activity of serum phosphatases in albino mice. Values of acid phosphatase activities were significantly higher in untreated irradiated group throughout the experiment. Irradiated animals pretreated with ME showed significant decline in acid phosphatase activity as compared to untreated irradiated animals at all autopsy intervals and attained normalcy at day 5. A marked decrease in serum alkaline phosphatase activity was recorded in both irradiated groups. However, in ME pretreated irradiated group, values of alkaline phosphatase activity remained significantly higher than untreated irradiated animals at all intervals and attained normalcy from day 5 onwards.

摘要

在全身照射（8 Gy）前连续三天口服给予薄荷提取物（ME；1 g/kg体重），结果显示其对白化病小鼠血清磷酸酶活性有调节作用。在整个实验过程中，未处理的照射组酸性磷酸酶活性值显著更高。与未处理的照射动物相比，用ME预处理的照射动物在所有尸检间隔时酸性磷酸酶活性均显著下降，并在第5天恢复正常。两个照射组的血清碱性磷酸酶活性均有显著降低。然而，在ME预处理的照射组中，碱性磷酸酶活性值在所有间隔时均显著高于未处理的照射动物，并从第5天起恢复正常。